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Alzheimer Dementia, sporadic, association marker APP

Neurology 10.007

Alzheimer Dementia, sporadic, association marker APP

AD1
Signs/symptoms: Dementia, late onset, sporadic
Complications: Neuritic plaques and neurons with neurofibrillary tangles.
Early diagnosis/treatment: Yes
Association between a polymorphism in the human amyloid precursor protein (APP) gene and Alzheimer's disease (AD).

Material required:
Blood tubes: EDTA whole blood (do not freeze, do not centrifugate)
Mouth brush: Yes
Chromosomal localization: 21q21 OMIM number: 104760

Amyloid beta (A4) precursor protein (association marker)

APP

Gene regions tested:
Gene regions:
Amino acid positions: V717I
Nucleotide positions:
Test methods: Sequencing

Prices:

Switzerland:
8820.00 8811.01 8819.01
  TP REVAL: 250 TP Value: 0.9 CHF 225.00
Other europe: EUR 160.00
Other regions: USD call

References:
Goate A, Chartier-Harlin MC, Mullan M, Brown J, Crawford F, Fidani L, Giuffra L, Haynes A, Irving N, James L, et al. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature. 1991;349:704-706.

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