Alzheimer Dementia, sporadic association marker PS1

Neurology

10.002

Alzheimer Dementia, sporadic association marker PS1

AD3

Signs/symptoms:	Dementia, late onset, sporadic
Complications:	Neuritic plaques and neurons with neurofibrillary tangles.
Early diagnosis/treatment:	Yes

Association between a polymorphism in the human presenilin (PSEN1) gene and Alzheimer's disease (AD).

Material required:
Blood tubes:	EDTA whole blood (do not freeze, do not centrifugate)
Mouth brush:	Yes

Chromosomal localization:

14q24.3

OMIM number:

104311

Presenilin 1 (association marker)

PS1

Gene regions tested:
Gene regions:
Amino acid positions:
Nucleotide positions:	nt(-48)C to T
Test methods:	Sequencing

Prices:

Switzerland:

8820.00

8811.01

8819.01

	TP REVAL:	250	TP Value:	0.9	CHF	225.00
Other europe:	EUR					160.00
Other regions:	USD					call

References:

Theuns J, Del-Favero J, Dermaut B, van Duijn CM, Backhovens H, Van den Broeck MV, Serneels S, Corsmit E, Van Broeckhoven CV, Cruts M. Genetic variability in the regulatory region of presenilin 1 associated with risk for Alzheimer's disease and variable expression. Hum Mol Genet. 2000;9:325-331.

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Alzheimer Dementia, sporadic association marker PS1