Alzheimer Dementia, sporadic association marker CST3

Neurology

10.001

Alzheimer Dementia, sporadic association marker CST3

AD2

Signs/symptoms:	Dementia, late onset, sporadic
Complications:	Neuritic plaques and neurons with neurofibrillary tangles.
Early diagnosis/treatment:	Yes

Cerebral amyloid angiopathy. Cerebral amyloid angiopathy, defined by the deposition of congophilic material in the vessels of the cortex and leptomeninges, is a major cause of intracerebral hemorrhage in the elderly.

Material required:
Blood tubes:	EDTA whole blood (do not freeze, do not centrifugate)
Mouth brush:	Yes

Chromosomal localization:

20p11.2

OMIM number:

604312

Cystatin C (association marker)

Cystatin C Gene

Gene regions tested:
Gene regions:
Amino acid positions:	A25T
Nucleotide positions:
Test methods:	Sequencing

Prices:

Switzerland:

8820.00

8811.01

8819.01

	TP REVAL:	250	TP Value:	0.9	CHF	225.00
Other europe:	EUR					160.00
Other regions:	USD					call

References:

Balbin M, Grubb A, Abrahamson M. An Ala/Thr variation in the coding region of the human cystatin C gene (CST3) detected as a SstII polymorphism. Hum Genet. 1993;92:206-207.

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Alzheimer Dementia, sporadic association marker CST3