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Coumarine Efficacy (VKORC1, drug side effects)

Angiology 05.002

Coumarine Efficacy (VKORC1, drug side effects)

PHGN
Signs/symptoms: Efficacy of coumarin derivatives
Complications: Thrombosis or bleeding.
Early diagnosis/treatment: Yes

Material required:
Blood tubes: EDTA whole blood (do not freeze, do not centrifugate)
Mouth brush: Yes
Chromosomal localization: 16p11.2 OMIM number: 608547

Vitamin K epoxide reductase complex, subunit 1

VKORC1

Gene regions tested:
Gene regions:
Amino acid positions:
Nucleotide positions: nt–1639G to A
Test methods: Sequencing

Prices:

Switzerland:
8820.00 8811.01 8819.01
  TP REVAL: 250 TP Value: 0.9 CHF 225.00
Other europe: EUR 160.00
Other regions: USD call

References:
Rost S, Fregin A, Ivaskevicius V, Conzelmann E, Hortnagel K, Pelz HJ, Lappegard K, Seifried E, Scharrer I, Tuddenham EG, Muller CR, Strom TM, Oldenburg J. Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2. Nature. 2004;427:537-541.

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