Thrombophilia Association Marker PAI1

Cardiology

04.030

Thrombophilia Association Marker PAI1

ATHSCL

Signs/symptoms:	Thrombosis
Complications:	Atherothrombosis
Early diagnosis/treatment:	Yes

Thrombophilia due to excessive plasminogen activator inhibitor 1. Increased PAI1 plasma levels are related to a 1-bp guanine deletion/insertion (4G/5G) polymorphism in the promoter of the PAI1 gene. Evidence suggested that the plasma levels of PAI1 modulate the risk of coronary artery disease; furthermore, that the 4G/5G polymorphism affects the expression of the PAI1 gene.

Material required:
Blood tubes:	EDTA whole blood (do not freeze, do not centrifugate)
Mouth brush:	Yes

Chromosomal localization:

7q21.3-q22

OMIM number:

173360

Plasminogen activator inhibitor 1 (insertions/deletions polymorphism)

PAI1

Gene regions tested:
Gene regions:
Amino acid positions:	4G/5G
Nucleotide positions:
Test methods:	Sequencing

Prices:

Switzerland:

8820.00

8811.01

8819.01

	TP REVAL:	300	TP Value:	0.9	CHF	270.00
Other europe:	EUR					190.00
Other regions:	USD					call

References:

Dawson SJ, Wiman B, Hamsten A, Green F, Humphries S, Henney AM. The two allele sequences of a common polymorphism in the promoter of the plasminogen activator inhibitor-1 (PAI-1) gene respond differently to interleukin-1 in HepG2 cells. J. Biol. Chem. 268: 10739-10745, 1993.

Eriksson P, Kallin B, van t'Hooft FM, Bavhenolm P, Hamsten A. Allelic-specific increase in basal transcription of the plasminogen-activator inhibitor 1 gene is associated with myocardial infarction. Proc. Nat. Acad. Sci. 92:1851-1855,1995.

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Thrombophilia Association Marker PAI1