APC Resistance / Thrombophilia (F5, Leiden mutation)

Cardiology

04.003

APC Resistance / Thrombophilia (F5, Leiden mutation)

ATHSCL

Signs/symptoms:	Myocardial infarction
Complications:	Atherothrombosis
Early diagnosis/treatment:	Yes

Thromboembolism susceptibility increased

Material required:
Blood tubes:	EDTA whole blood (do not freeze, do not centrifugate)
Mouth brush:	Yes

Chromosomal localization:

1q23

OMIM number:

227400

Coagulation factor V / proaccelerin (F5, Leiden mutation)

F5

Gene regions tested:
Gene regions:		Leiden Variant
Amino acid positions:	R506Q
Nucleotide positions:
Test methods:	Sequencing

Prices:

Switzerland:

8820.00

8811.01

8818.00

8819.01

8810.13

	TP REVAL:	270	TP Value:	0.9	CHF	243.00
Other europe:	EUR					180.00
Other regions:	USD					call

References:

Kim RJ, Becker RC. Association between factor V Leiden, prothrombin G20210A, and methylenetetrahydrofolate reductase C677T mutations and events of the arterial circulatory system: a meta-analysis of published studies. Am Heart J. 2003;146:948-957.

Braun A, Müller B, Rosche AA. Population study of the G1691A mutation (R506Q, FV Leiden) in the human factor V gene that is associated with resistance to activated protein C. Hum Genet (1996) 97: 263–264.

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APC Resistance / Thrombophilia (F5, Leiden mutation)